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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P04637: Variant p.Ser269Cys

Cellular tumor antigen p53
Gene: TP53
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Variant information Variant position: help 269
Type of variant: help US
Residue change: help From Serine (S) to Cysteine (C) at position 269 (S269C, p.Ser269Cys).
Physico-chemical properties: help Change from small size and polar (S) to medium size and polar (C)
BLOSUM score: help -1
Variant description: help In sporadic cancers; somatic mutation.


Sequence information Variant position: help 269
Protein sequence length: help 393
Location on the sequence: help RPILTIITLEDSSGNLLGRN S FEVRVCACPGRDRRTEEENL
Residue conservation: help 
Human                         RPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENL

                              RPILTIITLEDSSGNVLGRNSFEVRVCACPGRDRRTEEENF

Rhesus macaque                RPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENF

Mouse                         RPILTIITLEDSSGNLLGRDSFEVRVCACPGRDRRTEEENF

Rat                           RPILTIITLEDSSGNLLGRDSFEVRVCACPGRDRRTEEENF

Pig                           RPILTIITLEDASGNLLGRNSFEVRVCACPGRDRRTEEENF

Bovine                        RPILTIITLEDSCGNLLGRNSFEVRVCACPGRDRRTEEENL

Rabbit                        RPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENF

Sheep                         RPILTIITLEDSRGNLLGRSSFEVRVCACPGRDRRTEEENF

Cat                           RPIITIITLEDSNGKLLGRNSFEVRVCACPGRDRRTEEENF

Chicken                       RPILTILTLEGPGGQLLGRRCFEVRVCACPGRDRKIEEENF

Xenopus laevis                RPILTIITLETPQGLLLGRRCFEVRVCACPGRDRRTEEDNY

Zebrafish                     RPILTIITLETQEGQLLGRRSFEVRVCACPGRDRKTEESNF
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 1 – 393 Cellular tumor antigen p53
DNA binding 102 – 292
Region 1 – 320 Interaction with CCAR2
Region 100 – 370 Interaction with HIPK1
Region 100 – 300 Required for interaction with ZNF385A
Region 116 – 292 Interaction with AXIN1
Region 256 – 294 Interaction with E4F1
Modified residue 269 – 269 Phosphoserine; by AURKB
Modified residue 284 – 284 Phosphothreonine; by AURKB
Mutagenesis 269 – 269 S -> A. Abolishes phosphorylation.
Mutagenesis 269 – 269 S -> E. Inhibits strongly its transcriptional activity.
Mutagenesis 284 – 284 T -> E. Inhibits strongly its transcriptional activity.
Beta strand 264 – 274



Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.