Sequence information
Variant position: 282 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 393 The length of the canonical sequence.
Location on the sequence:
GNLLGRNSFEVRVCACPGRD
R RTEEENLRKKGEPHHELPPG
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human GNLLGRNSFEVRVCACPGRDR RTEEENLRKKGEPH--HELPPG
GNVLGRNSFEVRVCACPGRDR RTEEENFHKKGEPC--PEPP
Rhesus macaque GNLLGRNSFEVRVCACPGRDR RTEEENFRKKGEPC--HQLP
Mouse GNLLGRDSFEVRVCACPGRDR RTEEENFRKKEVLC--PELP
Rat GNLLGRDSFEVRVCACPGRDR RTEEENFRKKEEHC--PELP
Pig GNLLGRNSFEVRVCACPGRDR RTEEENFLKKGQSC--PEPP
Bovine GNLLGRNSFEVRVCACPGRDR RTEEENLRKKGQSC--PEPP
Rabbit GNLLGRNSFEVRVCACPGRDR RTEEENFRKKGEPC--PELP
Sheep GNLLGRSSFEVRVCACPGRDR RTEEENFRKKGQSC--PEPP
Cat GKLLGRNSFEVRVCACPGRDR RTEEENFRKKGEPC--PEPP
Chicken GQLLGRRCFEVRVCACPGRDR KIEEENFRKRGGAG------
Xenopus laevis GLLLGRRCFEVRVCACPGRDR RTEEDNYTKKRGLK-----P
Zebrafish GQLLGRRSFEVRVCACPGRDR KTEESNFKKDQETKTMAKTT
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
1 – 393
Cellular tumor antigen p53
DNA binding
102 – 292
Region
1 – 320
Interaction with CCAR2
Region
100 – 370
Interaction with HIPK1
Region
100 – 300
Required for interaction with ZNF385A
Region
116 – 292
Interaction with AXIN1
Region
256 – 294
Interaction with E4F1
Region
282 – 325
Disordered
Compositional bias
282 – 301
Basic and acidic residues
Modified residue
269 – 269
Phosphoserine; by AURKB
Modified residue
284 – 284
Phosphothreonine; by AURKB
Cross
291 – 291
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
Cross
292 – 292
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
Mutagenesis
269 – 269
S -> A. Abolishes phosphorylation.
Mutagenesis
269 – 269
S -> E. Inhibits strongly its transcriptional activity.
Mutagenesis
284 – 284
T -> E. Inhibits strongly its transcriptional activity.
Helix
278 – 287
Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.