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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P04637: Variant p.Asn288Tyr

Cellular tumor antigen p53
Gene: TP53
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Variant information Variant position: help 288
Type of variant: help US
Residue change: help From Asparagine (N) to Tyrosine (Y) at position 288 (N288Y, p.Asn288Tyr).
Physico-chemical properties: help Change from medium size and polar (N) to large size and aromatic (Y)
BLOSUM score: help -2
Variant description: help In sporadic cancers; somatic mutation.


Sequence information Variant position: help 288
Protein sequence length: help 393
Location on the sequence: help NSFEVRVCACPGRDRRTEEE N LRKKGEPHHELPPGSTKRAL
Residue conservation: help 
Human                         NSFEVRVCACPGRDRRTEEENLRKKGEPH--HELPPGSTKRAL

                              NSFEVRVCACPGRDRRTEEENFHKKGEPC--PEPPPGSTKR

Rhesus macaque                NSFEVRVCACPGRDRRTEEENFRKKGEPC--HQLPPGSTKR

Mouse                         DSFEVRVCACPGRDRRTEEENFRKKEVLC--PELPPGSAKR

Rat                           DSFEVRVCACPGRDRRTEEENFRKKEEHC--PELPPGSAKR

Pig                           NSFEVRVCACPGRDRRTEEENFLKKGQSC--PEPPPGSTKR

Bovine                        NSFEVRVCACPGRDRRTEEENLRKKGQSC--PEPPPRSTKR

Rabbit                        NSFEVRVCACPGRDRRTEEENFRKKGEPC--PELPPGSSKR

Sheep                         SSFEVRVCACPGRDRRTEEENFRKKGQSC--PEPPPGSTKR

Cat                           NSFEVRVCACPGRDRRTEEENFRKKGEPC--PEPPPGSTKR

Chicken                       RCFEVRVCACPGRDRKIEEENFRKRGGAG-------GVAKR

Xenopus laevis                RCFEVRVCACPGRDRRTEEDNYTKKRGLK-----PSGKREL

Zebrafish                     RSFEVRVCACPGRDRKTEESNFKKDQETKTMAKTTTGTKRS
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 1 – 393 Cellular tumor antigen p53
DNA binding 102 – 292
Region 1 – 320 Interaction with CCAR2
Region 100 – 370 Interaction with HIPK1
Region 100 – 300 Required for interaction with ZNF385A
Region 116 – 292 Interaction with AXIN1
Region 256 – 294 Interaction with E4F1
Region 282 – 325 Disordered
Compositional bias 282 – 299 Basic and acidic residues
Modified residue 269 – 269 Phosphoserine; by AURKB
Modified residue 284 – 284 Phosphothreonine; by AURKB
Modified residue 305 – 305 N6-acetyllysine
Cross 291 – 291 Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
Cross 292 – 292 Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
Mutagenesis 269 – 269 S -> A. Abolishes phosphorylation.
Mutagenesis 269 – 269 S -> E. Inhibits strongly its transcriptional activity.
Mutagenesis 284 – 284 T -> E. Inhibits strongly its transcriptional activity.
Helix 288 – 290



Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.