Variant position: 324 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 393 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human TKRALPNNTS-SSPQPK----KK----PL DGEYFTLQIRGRERFEMFREL
Rhesus macaque TKRALPNNTS-SSPQPK----KK----PL DGEYFTLQIRGR
Mouse AKRALPTCTS-ASPPQK----KK----PL DGEYFTLKIRGR
Rat AKRALPTSTS-SSPQQK----KK----PL DGEYFTLKIRGR
Pig TKRALPTSTS-SSPVQK----KK----PL DGEYFTLQIRGR
Bovine TKRALPTNTS-SSPQPK----KK----PL DGEYFTLQIRGF
Rabbit SKRALPTTTTDSSPQTK----KK----PL DGEYFILKIRGR
Sheep TKRALPSSTS-SSPQQK----KK----PL DGEYFTLQIRGR
Cat TKRALPPSTS-STPPQK----KK----PL DGEYFTLQIRGR
Chicken AKRAMSPPTE-APEPPK----KR--VLNP DNEIFYLQVRGR
Xenopus laevis RELAHPPSSE--PPLPK----KRLVVVDD DEEIFTLRIKGR
Zebrafish KRSLVKESSS-ATLRPEGSKKAK--GSSS DEEIFTLQVRGR
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 393 Cellular tumor antigen p53
100 – 370 Interaction with HIPK1
300 – 393 Interaction with CARM1
319 – 360 Interaction with HIPK2
305 – 305 N6-acetyllysine
315 – 315 Phosphoserine; by AURKA, CDK1 and CDK2
321 – 321 N6-acetyllysine
319 – 319 K -> A. Loss of nuclear localization; when associated with A-320 and A-321.
320 – 320 K -> A. Loss of nuclear localization; when associated with A-319 and A-321.
321 – 321 K -> A. Loss of nuclear localization; when associated with A-319 and A-320.
No reference for the current variant in UniProtKB/Swiss-Prot.
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.