Variant position: 344 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 393 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human DGEYFTLQIRGRERFEMFRE LNEALELKDAQAGKEPGGSRA---
Rhesus macaque DGEYFTLQIRGRERFEMFRE LNEALELKDAQAGKEPAGSRA
Mouse DGEYFTLKIRGRKRFEMFRE LNEALELKDAHATEESGDSRA
Rat DGEYFTLKIRGRERFEMFRE LNEALELKDARAAEESGDSRA
Pig DGEYFTLQIRGRERFEMFRE LNDALELKDAQTARESGENRA
Bovine DGEYFTLQIRGFKRYEMFRE LNDALELKDALDGREPGESRA
Rabbit DGEYFILKIRGRERFEMFRE LNEALELKDAQAEKEPGGSRA
Sheep DGEYFTLQIRGRKRFEMFRE LNEALELMDAQAGREPGESRA
Cat DGEYFTLQIRGRERFEMFRE LNEALELKDAQSGKEPGGSRA
Chicken DNEIFYLQVRGRRRYEMLKE INEALQLAEGGSAPRPSKGRR
Xenopus laevis DEEIFTLRIKGRSRYEMIKK LNDALELQESLDQQKV-----
Zebrafish DEEIFTLQVRGRERYEILKK LNDSLELSDVVPASDAEKYRQ
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 393 Cellular tumor antigen p53
100 – 370 Interaction with HIPK1
300 – 393 Interaction with CARM1
319 – 360 Interaction with HIPK2
325 – 356 Oligomerization
339 – 350 Nuclear export signal
332 – 346 IRGRERFEMFRELNE -> MLLDLRWCYFLINSS. In isoform 3, isoform 6 and isoform 9.
342 – 393 Missing. In isoform 2, isoform 5 and isoform 8.
359 – 359 P -> D. Abolishes binding to USP7.
361 – 361 G -> E. Abolishes binding to USP7.
362 – 362 S -> A. Abolishes binding to USP7.
335 – 354
No reference for the current variant in UniProtKB/Swiss-Prot.
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.