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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P04637: Variant p.Arg158Phe

Cellular tumor antigen p53
Gene: TP53
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Variant information Variant position: help 158
Type of variant: help US
Residue change: help From Arginine (R) to Phenylalanine (F) at position 158 (R158F, p.Arg158Phe).
Physico-chemical properties: help Change from large size and basic (R) to large size and aromatic (F)
BLOSUM score: help -3
Variant description: help In a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions.


Sequence information Variant position: help 158
Protein sequence length: help 393
Location on the sequence: help AKTCPVQLWVDSTPPPGTRV R AMAIYKQSQHMTEVVRRCPH
Residue conservation: help 
Human                         AKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPH

                              AKTCPVQLWVSSPPPPNTCVRAMAIYKKSEFVTEVVRRCPH

Rhesus macaque                AKTCPVQLWVDSTPPPGSRVRAMAIYKQSQHMTEVVRRCPH

Mouse                         AKTCPVQLWVSATPPAGSRVRAMAIYKKSQHMTEVVRRCPH

Rat                           AKTCPVQLWVTSTPPPGTRVRAMAIYKKSQHMTEVVRRCPH

Pig                           AKTCPVQLWVSSPPPPGTRVRAMAIYKKSEYMTEVVRRCPH

Bovine                        AKTCPVQLWVDSPPPPGTRVRAMAIYKKLEHMTEVVRRCPH

Rabbit                        AKTCPVQLWVDSTPPPGTRVRAMAIYKKSQHMTEVVRRCPH

Sheep                         AKTCPVQLWVDSPPPPGTRVRAMAIYKKLEHMTEVVRRSPH

Cat                           AKTCPVQLWVRSPPPPGTCVRAMAIYKKSEFMTEVVRRCPH

Chicken                       AKPCPVQVRVGVAPPPGSSLRAVAVYKKSEHVAEVVRRCPH

Xenopus laevis                AKTCPLLVRVESPPPRGSILRATAVYKKSEHVAEVVKRCPH

Zebrafish                     AKTCPVQMVVDVAPPQGSVVRATAIYKKSEHVAEVVRRCPH
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 1 – 393 Cellular tumor antigen p53
DNA binding 102 – 292
Region 1 – 320 Interaction with CCAR2
Region 100 – 370 Interaction with HIPK1
Region 100 – 300 Required for interaction with ZNF385A
Region 113 – 236 Required for interaction with FBXO42
Region 116 – 292 Interaction with AXIN1
Binding site 176 – 176
Modified residue 139 – 139 N6-lactoyllysine
Beta strand 156 – 165



Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.