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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P04637: Variant p.Val173Trp

Cellular tumor antigen p53
Gene: TP53
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Variant information Variant position: help 173
Type of variant: help US
Residue change: help From Valine (V) to Tryptophan (W) at position 173 (V173W, p.Val173Trp).
Physico-chemical properties: help Change from medium size and hydrophobic (V) to large size and aromatic (W)
BLOSUM score: help -3
Variant description: help In a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions.


Sequence information Variant position: help 173
Protein sequence length: help 393
Location on the sequence: help PGTRVRAMAIYKQSQHMTEV V RRCPHHERCSDSDGLAPPQH
Residue conservation: help 
Human                         PGTRVRAMAIYKQSQHMTEVVRRCPHHERCSD-SDGLAPPQH

                              PNTCVRAMAIYKKSEFVTEVVRRCPHHERCSDSSDGLAPPQ

Rhesus macaque                PGSRVRAMAIYKQSQHMTEVVRRCPHHERCSD-SDGLAPPQ

Mouse                         AGSRVRAMAIYKKSQHMTEVVRRCPHHERCSD-GDGLAPPQ

Rat                           PGTRVRAMAIYKKSQHMTEVVRRCPHHERCSD-GDGLAPPQ

Pig                           PGTRVRAMAIYKKSEYMTEVVRRCPHHERSSDYSDGLAPPQ

Bovine                        PGTRVRAMAIYKKLEHMTEVVRRCPHHERSSDYSDGLAPPQ

Rabbit                        PGTRVRAMAIYKKSQHMTEVVRRCPHHERCSD-SDGLAPPQ

Sheep                         PGTRVRAMAIYKKLEHMTEVVRRSPHHERSSDYSDGLAPPQ

Cat                           PGTCVRAMAIYKKSEFMTEVVRRCPHHERCPDSSDGLAPPQ

Chicken                       PGSSLRAVAVYKKSEHVAEVVRRCPHHERCGGGTDGLAPAQ

Xenopus laevis                RGSILRATAVYKKSEHVAEVVKRCPHHERSVEPGEDAAPPS

Zebrafish                     QGSVVRATAIYKKSEHVAEVVRRCPHHERTPD-GDNLAPAG
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 1 – 393 Cellular tumor antigen p53
DNA binding 102 – 292
Region 1 – 320 Interaction with CCAR2
Region 100 – 370 Interaction with HIPK1
Region 100 – 300 Required for interaction with ZNF385A
Region 113 – 236 Required for interaction with FBXO42
Region 116 – 292 Interaction with AXIN1
Binding site 176 – 176
Binding site 179 – 179
Modified residue 183 – 183 Phosphoserine; by AURKB
Mutagenesis 183 – 183 S -> A. Abolishes strongly phosphorylation.
Mutagenesis 183 – 183 S -> E. Inhibits slightly its transcriptional activity.



Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.