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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P04637: Variant p.Asp259Pro

Cellular tumor antigen p53
Gene: TP53
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Variant information Variant position: help 259
Type of variant: help US
Residue change: help From Aspartate (D) to Proline (P) at position 259 (D259P, p.Asp259Pro).
Physico-chemical properties: help Change from medium size and acidic (D) to medium size and hydrophobic (P)
BLOSUM score: help -1
Variant description: help In a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions.


Sequence information Variant position: help 259
Protein sequence length: help 393
Location on the sequence: help NSSCMGGMNRRPILTIITLE D SSGNLLGRNSFEVRVCACPG
Residue conservation: help 
Human                         NSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPG

                              NSSCMGGMNRRPILTIITLEDSSGNVLGRNSFEVRVCACPG

Rhesus macaque                NSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPG

Mouse                         NSSCMGGMNRRPILTIITLEDSSGNLLGRDSFEVRVCACPG

Rat                           NSSCMGGMNRRPILTIITLEDSSGNLLGRDSFEVRVCACPG

Pig                           NSSCMGGMNRRPILTIITLEDASGNLLGRNSFEVRVCACPG

Bovine                        NSSCMGGMNRRPILTIITLEDSCGNLLGRNSFEVRVCACPG

Rabbit                        NSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPG

Sheep                         NSSCMGGMNRRPILTIITLEDSRGNLLGRSSFEVRVCACPG

Cat                           NSSCMGGMNRRPIITIITLEDSNGKLLGRNSFEVRVCACPG

Chicken                       NSSCMGGMNRRPILTILTLEGPGGQLLGRRCFEVRVCACPG

Xenopus laevis                NSSCMGGMNRRPILTIITLETPQGLLLGRRCFEVRVCACPG

Zebrafish                     NSSCMGGMNRRPILTIITLETQEGQLLGRRSFEVRVCACPG
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 1 – 393 Cellular tumor antigen p53
DNA binding 102 – 292
Region 1 – 320 Interaction with CCAR2
Region 100 – 370 Interaction with HIPK1
Region 100 – 300 Required for interaction with ZNF385A
Region 116 – 292 Interaction with AXIN1
Region 256 – 294 Interaction with E4F1
Binding site 242 – 242
Modified residue 269 – 269 Phosphoserine; by AURKB
Mutagenesis 248 – 248 R -> S. Does not induce SNAI1 degradation.
Mutagenesis 269 – 269 S -> A. Abolishes phosphorylation.
Mutagenesis 269 – 269 S -> E. Inhibits strongly its transcriptional activity.



Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.