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UniProtKB/Swiss-Prot P01112: Variant p.Thr58Ile

GTPase HRas
Gene: HRAS
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Variant information Variant position: help 58 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Type of variant: help LP/P [Disclaimer] The variants are classified into three categories: LP/P, LB/B and US.
  • LP/P: likely pathogenic or pathogenic.
  • LB/B: likely benign or benign.
  • US: uncertain significance

Residue change: help From Threonine (T) to Isoleucine (I) at position 58 (T58I, p.Thr58Ile). Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.
Physico-chemical properties: help Change from medium size and polar (T) to medium size and hydrophobic (I) The physico-chemical property of the reference and variant residues and the change implicated.
BLOSUM score: help -1 The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page

Variant description: help In CSTLO. Any additional useful information about the variant.
Other resources: help Links to websites of interest for the variant.


Sequence information Variant position: help 58 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: help 189 The length of the canonical sequence.
Location on the sequence: help DSYRKQVVIDGETCLLDILD T AGQEEYSAMRDQYMRTGEGF The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: help The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human                         DSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGF

Mouse                         DSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGF

Rat                           DSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGF

Chicken                       DSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGF

Sequence annotation in neighborhood: help The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.
TypePositionsDescription
Chain 1 – 186 GTPase HRas
Chain 2 – 186 GTPase HRas, N-terminally processed
Mutagenesis 38 – 38 D -> N. No effect on interaction with PLCE1; when associated with V-12.
Mutagenesis 39 – 39 S -> C. No effect on interaction with PLCE1; when associated with V-12.
Mutagenesis 59 – 59 A -> T. Loss of GTPase activity and creation of an autophosphorylation site.
Mutagenesis 61 – 61 Q -> I. Moderately increased transformation of cultured cell lines.
Mutagenesis 61 – 61 Q -> V. Strongly increased transformation of cultured cell lines.



Literature citations
Costello syndrome associated with novel germline HRAS mutations: an attenuated phenotype?
Gripp K.W.; Innes A.M.; Axelrad M.E.; Gillan T.L.; Parboosingh J.S.; Davies C.; Leonard N.J.; Lapointe M.; Doyle D.; Catalano S.; Nicholson L.; Stabley D.L.; Sol-Church K.;
Am. J. Med. Genet. A 146:683-690(2008)
Cited for: VARIANTS CSTLO ILE-58 AND VAL-146;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.