Sequence information
Variant position: 391 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 2221 The length of the canonical sequence.
Location on the sequence:
WVNDAVGRDWPWIYFVTLII
I GSFFVLNLVLGVLSGEFSKE
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human WVNDAVGRDWPWIYFVTLIII GSFFVLNLVLGVLSGEFSKE
Mouse WMQDAMGYELPWVYFVSLVIF GSFFVLNLVLGVLSGEFSKE
Rat WMQDAMGYELPWVYFVSLVIF GSFFVLNLVLGVLSGEFSKE
Rabbit WMQDAMGYELPWVYFVSLVIF GSFFVLNLVLGVLSGEFSKE
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
1 – 2221
Voltage-dependent L-type calcium channel subunit alpha-1C
Transmembrane
381 – 401
Helical; Name=S6 of repeat I
Repeat
111 – 408
I
Alternative sequence
372 – 391
VNDAVGRDWPWIYFVTLIII -> MQDAMGYELPWVYFVSLVIF. In isoform 3, isoform 16, isoform 17, isoform 18, isoform 23, isoform 28, isoform 36 and isoform 37.
Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.