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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot Q8N4C8: Variant p.Val771Ala

Misshapen-like kinase 1
Gene: MINK1
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Variant information Variant position: help 771
Type of variant: help LB/B
Residue change: help From Valine (V) to Alanine (A) at position 771 (V771A, p.Val771Ala).
Physico-chemical properties: help Change from medium size and hydrophobic (V) to small size and hydrophobic (A)
BLOSUM score: help 0
Other resources: help


Sequence information Variant position: help 771
Protein sequence length: help 1332
Location on the sequence: help LPASHGHLPQAGSLERNRVG V SSKPDSSPVLSPGNKAKPDD
Residue conservation: help 
Human                         LPASHGHLPQAGSLE--RNRVGVSSKPDSSPVLSPGNKAKPDD

Mouse                         LPASHGHLPQAGSLERNRNRVGASTKLDSSPVLSPGNKAKP

Rat                           LPASHGHLPQAGSLERNRNRVGASTKLDSSPVLSPGNKAKP
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 1 – 1332 Misshapen-like kinase 1
Region 395 – 887 Disordered
Modified residue 754 – 754 Phosphoserine
Modified residue 763 – 763 Phosphoserine
Modified residue 777 – 777 Phosphoserine
Modified residue 778 – 778 Phosphoserine
Modified residue 782 – 782 Phosphoserine



Literature citations
Identification and functional characterization of a novel human misshapen/Nck interacting kinase-related kinase, hMINK beta.
Hu Y.; Leo C.; Yu S.; Huang B.C.; Wang H.; Shen M.; Luo Y.; Daniel-Issakani S.; Payan D.G.; Xu X.;
J. Biol. Chem. 279:54387-54397(2004)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4); FUNCTION; SUBCELLULAR LOCATION; INTERACTION WITH NCK1; TISSUE SPECIFICITY; ALTERNATIVE SPLICING; AUTOPHOSPHORYLATION; VARIANTS ALA-771 AND LEU-775; The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
The MGC Project Team;
Genome Res. 14:2121-2127(2004)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3); VARIANTS ALA-771 AND LEU-775;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.