UniProtKB/SwissProt variant VAR

Dual specificity mitogen-activated protein kinase kinase 3
Gene: MAP2K3
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Variant information Variant position:

84
Type of variant:

LB/B
Residue change:

From Alanine (A) to Threonine (T) at position 84 (A84T, p.Ala84Thr).
Physico-chemical properties:

Change from small size and hydrophobic (A) to medium size and polar (T)
BLOSUM score:

0
Other resources:

Variant rs2305873 [ dbSNP | Ensembl ]

Sequence information Variant position:

84
Protein sequence length:

347
Location on the sequence:

LVTISELGRGAYGVVEKVRH A QSGTIMAVKRIRATVNSQEQ
Residue conservation:

Human                         LVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQ

Mouse                         LVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNTQEQ

Sequence annotation in neighborhood:

Type	Positions	Description
Chain	1 – 347	Dual specificity mitogen-activated protein kinase kinase 3
Domain	64 – 325	Protein kinase
Binding site	93 – 93

Literature citations
Patterns of somatic mutation in human cancer genomes.
Greenman C.; Stephens P.; Smith R.; Dalgliesh G.L.; Hunter C.; Bignell G.; Davies H.; Teague J.; Butler A.; Stevens C.; Edkins S.; O'Meara S.; Vastrik I.; Schmidt E.E.; Avis T.; Barthorpe S.; Bhamra G.; Buck G.; Choudhury B.; Clements J.; Cole J.; Dicks E.; Forbes S.; Gray K.; Halliday K.; Harrison R.; Hills K.; Hinton J.; Jenkinson A.; Jones D.; Menzies A.; Mironenko T.; Perry J.; Raine K.; Richardson D.; Shepherd R.; Small A.; Tofts C.; Varian J.; Webb T.; West S.; Widaa S.; Yates A.; Cahill D.P.; Louis D.N.; Goldstraw P.; Nicholson A.G.; Brasseur F.; Looijenga L.; Weber B.L.; Chiew Y.-E.; DeFazio A.; Greaves M.F.; Green A.R.; Campbell P.; Birney E.; Easton D.F.; Chenevix-Trench G.; Tan M.-H.; Khoo S.K.; Teh B.T.; Yuen S.T.; Leung S.Y.; Wooster R.; Futreal P.A.; Stratton M.R.;
Nature 446:153-158(2007)
Cited for: VARIANTS [LARGE SCALE ANALYSIS] THR-26; PRO-68; THR-84; ILE-90; LEU-94; TRP-96; HIS-293 AND MET-339;

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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P46734: Variant p.Ala84Thr