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UniProtKB/Swiss-Prot Q9UKP4: Variant p.Gly1583Ala

A disintegrin and metalloproteinase with thrombospondin motifs 7
Gene: ADAMTS7
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Variant information Variant position: help 1583
Type of variant: help LB/B
Residue change: help From Glycine (G) to Alanine (A) at position 1583 (G1583A, p.Gly1583Ala).
Physico-chemical properties: help Change from glycine (G) to small size and hydrophobic (A)
BLOSUM score: help 0
Other resources: help


Sequence information Variant position: help 1583
Protein sequence length: help 1686
Location on the sequence: help RPCNTHPCTQWVVGPWGQCS G PCGGGVQRRLVKCVNTQTGL
Residue conservation: help 
Human                         RPCNTHPCTQWVVGPWGQCSGPCGGGVQRRLVKCVNTQTGL

Mouse                         RPCNTHPCTQWVVGPWGQCSAPCGGGVQRRLVRCVNTQTGL

Rat                           RPCNTHPCTQWVVGPWGQCSAPCGGGVQRRLVKCVNTQTGL
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 237 – 1686 A disintegrin and metalloproteinase with thrombospondin motifs 7
Domain 1569 – 1629 TSP type-1 8



Literature citations
ADAMTS-7: a metalloproteinase that directly binds to and degrades cartilage oligomeric matrix protein.
Liu C.-J.; Kong W.; Ilalov K.; Yu S.; Xu K.; Prazak L.; Fajardo M.; Sehgal B.; Di Cesare P.E.;
FASEB J. 20:988-990(2006)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; FUNCTION; COFACTOR; PH DEPENDENCE; INTERACTION WITH COMP; INDUCTION; TISSUE SPECIFICITY; VARIANTS ALA-1319; SER-1414 AND ALA-1583;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.