Sequence information
Variant position: 398 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 468 The length of the canonical sequence.
Location on the sequence:
EETESGSGPKSSRNTLEAAL
D SIRYITRHIMKENDVREVVE
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human EETESGSGPKSSRNTLEAALD SIRYITRHIMKENDVREVVE
Chimpanzee EETESGSGPKSSRNTLEAALD SVRCITRHIMKENDVREVVE
Mouse EEAEKDGGPKS-RNTLEAALD CIRYITRHVVKENDVREVVE
Rat EEAESGAGPKS-RNTLEAALD CIRYITRHVVKENDVREVVE
Bovine EEARSSRGPRSSRNALEAALD SVRYITRHVMKETDVREVVE
Chicken EEKGNMSGSESSRNTLEAALD SIRYITRHVMKENEVREVVE
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
23 – 468
Neuronal acetylcholine receptor subunit alpha-5
Topological domain
338 – 429
Cytoplasmic
Literature citations
Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits.
Elliott K.J.; Ellis S.B.; Berckhan K.J.; Urrutia A.; Chavez-Noriega L.E.; Johnson E.C.; Velicelebi G.; Harpold M.M.;
J. Mol. Neurosci. 7:217-228(1996)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; VARIANT ASN-398;
Characterization of the genomic structure of human nicotinic acetylcholine receptor CHRNA5/A3/B4 gene cluster: identification of two novel introns in the 3' untranslated region of CHRNA3 and of a tail-to-tail overlap between CHRNA3 and CHRNA5.
Duga S.; Solda G.; Asselta R.; Bonati M.T.; Dalpra L.; Malcovati M.; Tenchini M.L.;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANT ASN-398;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.