Variant position: 208 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 1015 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human FSESILTYVAHTSALTYPPG SRTQLREDLLPRTLGQLQPDE
Mouse SPENILTYVAHTSALTYPPA TRAKYPDNLL-RPFSRLQPDE
Rat SPENILTYVAHTSALTYPPA TRVKYPDNLL-RPLSRLQPDE
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
22 – 1015 Receptor-type tyrosine-protein phosphatase N2
22 – 615 Extracellular
1 – 421 Involved in localization to secretory granules; interaction with CPE
Molecular cloning and characterization of the human transmembrane protein tyrosine phosphatase homologue, phogrin, an autoantigen of type 1 diabetes.
Kawasaki E.; Hutton J.C.; Eisenbarth G.S.;
Biochem. Biophys. Res. Commun. 227:440-447(1996)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); DOMAIN; ROLE IN DIABETES MELLITUS; VARIANT PRO-208;
Characterization and chromosomal localization of PTPRP, a receptor protein tyrosine phosphatase predominantly expressed in brain and pancreas.
Jiang S.; Tulloch G.; Fu Y.; London R.; Hummel G.S.; White R.A.; Avraham H.; Avraham S.;
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4); VARIANTS THR-140; PRO-208 AND ASN-325;
Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.
Nagase T.; Ishikawa K.; Nakajima D.; Ohira M.; Seki N.; Miyajima N.; Tanaka A.; Kotani H.; Nomura N.; Ohara O.;
DNA Res. 4:141-150(1997)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3); VARIANTS PRO-208 AND HIS-213;
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
The MGC Project Team;
Genome Res. 14:2121-2127(2004)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2); VARIANT PRO-208;
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