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UniProtKB/Swiss-Prot Q8IY92: Variant p.Ala1367Thr

Structure-specific endonuclease subunit SLX4
Gene: SLX4
Variant information

Variant position:  1367
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Type of variant:  LB/B
The variants are classified into three categories: LP/P, LB/B and US.
  • LP/P: likely pathogenic or pathogenic.
  • LB/B: likely benign or benign.
  • US: uncertain significance

Residue change:  From Alanine (A) to Threonine (T) at position 1367 (A1367T, p.Ala1367Thr).
Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.

Physico-chemical properties:  Change from small size and hydrophobic (A) to medium size and polar (T)
The physico-chemical property of the reference and variant residues and the change implicated.

BLOSUM score:  0
The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page

Other resources:  
Links to websites of interest for the variant.



Sequence information

Variant position:  1367
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Protein sequence length:  1834
The length of the canonical sequence.

Location on the sequence:   HPGGHPHSSPLAPHPISGDR  A HFSRRFLKHSPPGPSFLNQT
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.

Residue conservation: 
The multiple alignment of the region surrounding the variant against various orthologous sequences.

Human                         HPGGHPHSS--PLAPHPISGDRAHFSRRFLKHSPPGPSFLNQT

Mouse                         YPRHHRLSSSQPSCPGP------DFTRWSQKSSAPRPCLPN

Drosophila                    LSRRSSH----------------KFNELLAKISKPAH----

Baker's yeast                 NPKLVKH----------------NFYRVEANDSEE------

Fission yeast                 -----------------------------------------

Sequence annotation in neighborhood:  
The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.

TypePositionsDescription
Chain 1 – 1834 Structure-specific endonuclease subunit SLX4
Region 684 – 1834 Interaction with PLK1 and TERF2-TERF2IP
Region 1195 – 1504 Disordered
Region 1328 – 1648 Interaction with MUS81


Literature citations

No reference for the current variant in UniProtKB/Swiss-Prot.

Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.