Sequence information
Variant position: 18 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 1325 The length of the canonical sequence.
Location on the sequence:
MLPVYQEVKPNPLQDAN
L CSRVFFWWLNPLFKIGHKRR
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human MLPVYQEVKPNPLQDANL CSRVFFWWLNPLFKIGHKRR
Mouse MLPVHTEVKPNPLQDANL CSRVFFWWLNPLFKTGHKRR
Rat MLPVHTEVKPNPLQDANL CSRLFFWWLNPLFKAGHKRR
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
1 – 1325
ATP-binding cassette sub-family C member 4
Literature citations
Isolation of MOAT-B, a widely expressed multidrug resistance-associated protein/canalicular multispecific organic anion transporter-related transporter.
Lee K.; Belinsky M.G.; Bell D.W.; Testa J.R.; Kruh G.D.;
Cancer Res. 58:2741-2747(1998)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); VARIANT ILE-18;
Expression of MRP4 confers resistance to ganciclovir and compromises bystander cell killing.
Adachi M.; Sampath J.; Lan L.B.; Sun D.; Hargrove P.; Flatley R.; Tatum A.; Edwards M.Z.; Wezeman M.; Matherly L.; Drake R.; Schuetz J.;
J. Biol. Chem. 277:38998-39004(2002)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); VARIANT ILE-18; CATALYTIC ACTIVITY; FUNCTION;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.