Variant position: 11 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 215 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human MGKGDPKKPR GKMSSYAFFVQTCREEHKKKH
Mouse MGKGDPKKPR GKMSSYAFFVQTCREEHKKKH
Rat MGKGDPKKPR GKMSSYAFFVQTCREEHKKKH
Pig MGKGDPKKPR GKMSSYAFFVQTCREEHKKKH
Bovine MGKGDPKKPR GKMSSYAFFVQTCREEHKKKH
Horse MGKGDPKKPR GKMSSYAFFVQTCREEHKKKH
Chicken MGKGDPKKPR GKMSSYAFFVQTCREEHKKKH
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 215 High mobility group protein B1
9 – 79 HMG box 1
1 – 97 Sufficient for interaction with HAVCR2
3 – 15 LPS binding (delipidated)
10 – 11 Cleavage; by thrombin:thrombomodulin
3 – 3 N6-acetyllysine
7 – 7 N6-acetyllysine
8 – 8 N6-acetyllysine
12 – 12 N6-acetyllysine
23 – 23 Cysteine sulfonic acid (-SO3H); alternate
28 – 28 N6-acetyllysine
29 – 29 N6-acetyllysine
30 – 30 N6-acetyllysine
Expression of high-mobility group-1 mRNA in human gastrointestinal adenocarcinoma and corresponding non-cancerous mucosa.
Xiang Y.-Y.; Wang D.-Y.; Tanaka M.; Suzuki M.; Kiyokawa E.; Igarashi H.; Niato Y.; Shen Q.; Sugimura H.;
Int. J. Cancer 74:1-6(1997)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; VARIANTS ARG-11; GLU-149 AND GLY-190;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.