Variant position: 190 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 215 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human AAKKGVVKAEKSKKKKEEEE DEEDEEDEEEEEDEEDEDEEE
Mouse AAKKGVVKAEKSKKKKEEED DEEDEEDEEEEEEEEDEDEEE
Rat AAKKGVVKAEKSKKKKEEED DEEDEEDEEEEEEEEDEDEEE
Pig AAKKGVVKAEKSKKKKEEEE DEEDEEDEEEEEDEEDEEEEE
Bovine AAKKGVVKAEKSKKKKEEEE DEEDEEDEEEEEDEEDEEEEE
Horse AAKKGVVKAEKSKKKKEEEE DEEDEEDEEEEEDEEDEDEEE
Chicken AGKKVVAKAEKSKKKKEEEE DEDEDEEDEEDEEEEEEEEED
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 215 High mobility group protein B1
186 – 215 Asp/Glu-rich (acidic)
172 – 172 N6-acetyllysine
173 – 173 N6-acetyllysine
177 – 177 N6-acetyllysine
180 – 180 N6-acetyllysine
181 – 181 ADP-ribosylserine
182 – 182 N6-acetyllysine
183 – 183 N6-acetyllysine
184 – 184 N6-acetyllysine
185 – 185 N6-acetyllysine
181 – 181 S -> A. Greatly reduces phosphorylation, nuclear localization; when associated with A-35; A-39; A-42; A-46 and A-53.
181 – 181 S -> E. Cytoplasmic localization (phosphorylation mimicking); when associated with E-35; E-39; E-42; E-46 and E-53.
Expression of high-mobility group-1 mRNA in human gastrointestinal adenocarcinoma and corresponding non-cancerous mucosa.
Xiang Y.-Y.; Wang D.-Y.; Tanaka M.; Suzuki M.; Kiyokawa E.; Igarashi H.; Niato Y.; Shen Q.; Sugimura H.;
Int. J. Cancer 74:1-6(1997)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; VARIANTS ARG-11; GLU-149 AND GLY-190;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.