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UniProtKB/Swiss-Prot P09429: Variant p.Asp190Gly

High mobility group protein B1
Gene: HMGB1
Variant information

Variant position:  190
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Type of variant:  US
The variants are classified into three categories: LP/P, LB/B and US.
  • LP/P: likely pathogenic or pathogenic.
  • LB/B: likely benign or benign.
  • US: uncertain significance

Residue change:  From Aspartate (D) to Glycine (G) at position 190 (D190G, p.Asp190Gly).
Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.

Physico-chemical properties:  Change from medium size and acidic (D) to glycine (G)
The physico-chemical property of the reference and variant residues and the change implicated.

BLOSUM score:  -1
The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page

Variant description:  In gastric-carcinoma cell line.
Any additional useful information about the variant.



Sequence information

Variant position:  190
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Protein sequence length:  215
The length of the canonical sequence.

Location on the sequence:   AAKKGVVKAEKSKKKKEEEE  D EEDEEDEEEEEDEEDEDEEE
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.

Residue conservation: 
The multiple alignment of the region surrounding the variant against various orthologous sequences.

Human                         AAKKGVVKAEKSKKKKEEEEDEEDEEDEEEEEDEEDEDEEE

                              AAKKGVVKAEKSKKKKEEEEDEEDEEDEEEEEDEEDEDEEE

Mouse                         AAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEE

Rat                           AAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEE

Pig                           AAKKGVVKAEKSKKKKEEEEDEEDEEDEEEEEDEEDEEEEE

Bovine                        AAKKGVVKAEKSKKKKEEEEDEEDEEDEEEEEDEEDEEEEE

Horse                         AAKKGVVKAEKSKKKKEEEEDEEDEEDEEEEEDEEDEDEEE

Chicken                       AGKKVVAKAEKSKKKKEEEEDEDEDEEDEEDEEEEEEEEED

Sequence annotation in neighborhood:  
The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.

TypePositionsDescription
Chain 1 – 215 High mobility group protein B1
Region 161 – 215 Disordered
Compositional bias 188 – 215 Acidic residues
Modified residue 172 – 172 N6-acetyllysine
Modified residue 173 – 173 N6-acetyllysine
Modified residue 177 – 177 N6-acetyllysine
Modified residue 180 – 180 N6-acetyllysine
Modified residue 181 – 181 ADP-ribosylserine
Modified residue 182 – 182 N6-acetyllysine
Modified residue 183 – 183 N6-acetyllysine
Modified residue 184 – 184 N6-acetyllysine
Modified residue 185 – 185 N6-acetyllysine
Cross 180 – 180 Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-?)
Cross 182 – 182 Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-?)
Cross 183 – 183 Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-?)
Cross 184 – 184 Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-?)
Mutagenesis 181 – 181 S -> A. Greatly reduces phosphorylation, nuclear localization; when associated with A-35; A-39; A-42; A-46 and A-53.
Mutagenesis 181 – 181 S -> E. Cytoplasmic localization (phosphorylation mimicking); when associated with E-35; E-39; E-42; E-46 and E-53.


Literature citations

Expression of high-mobility group-1 mRNA in human gastrointestinal adenocarcinoma and corresponding non-cancerous mucosa.
Xiang Y.-Y.; Wang D.-Y.; Tanaka M.; Suzuki M.; Kiyokawa E.; Igarashi H.; Niato Y.; Shen Q.; Sugimura H.;
Int. J. Cancer 74:1-6(1997)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; VARIANTS ARG-11; GLU-149 AND GLY-190;

Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.