Variant position: 185 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 445 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human ALSSLWGKLASEILMQNWDA AMEDLTRLKETIDNNSVSSPL
Mouse ALSSLWGKLASEILMQNWDA AMEDLTRLKETIDNNSVSSPL
Rat ALSSLWGKLASEILMQNWDA AMEDLTRLKETIDNNSVSSPL
Bovine ALSSLWGKLASEILMQNWDA AMEDLTRLKETIDNNSVSSPL
Chicken ALSSLWGKLASEVLMQNWDA AMEDLTRLKETIDNNSVSSPL
Xenopus tropicalis ALSSLWGKLASEILMQNWDA AMEDLTRLKETIDNNTVSSPL
Caenorhabditis elegans YLNALYGKLASEILLQEWEH ARDDLLKLRAYIDANPFDTEW
Drosophila YLNVLWGKLAAEILTLNWNT ALEDLTRLRDYIDNANF-STI
Slime mold RLSALWGILESDILSLNWGQ AVGDISPLQDQIDSNG--TPV
Fission yeast A-SATWGKFASEILTVDWDG AMEELGKLREMVDSKSFKDSA
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
2 – 445 Eukaryotic translation initiation factor 3 subunit E
9 – 195 Sufficient for interaction with TRIM27
182 – 194
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
The MGC Project Team;
Genome Res. 14:2121-2127(2004)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]; VARIANT VAL-185;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.