Variant position: 313 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 581 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human VDYPDVL-PSRLHPEGLGHGR TLFLVMKNYPCTLRQYLCVNT
Mouse ADYPDML-PPHYYPEGLGHGR TLFLVMKNYPCTLRQYLEEQ
Rat ADYPDML-PPHYYPEGLGHGR TLFLVMKNYPCTLRQYLEEQ
Caenorhabditis elegans ERYPDALHTARWYESIASEPK TMYVVMRRYRQTLHEYVWTR
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
78 – 581 Serine/threonine-protein kinase PINK1, mitochondrial
111 – 581 Cytoplasmic
156 – 511 Protein kinase
308 – 320 LGHGRTLFLVMKN -> MCGSQRPSPLSTS. In isoform 2.
Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation.
Xiong H.; Wang D.; Chen L.; Choo Y.S.; Ma H.; Tang C.; Xia K.; Jiang W.; Ronai Z.; Zhuang X.; Zhang Z.;
J. Clin. Invest. 119:650-660(2009)
Cited for: FUNCTION; COMPONENT OF A COMPLEX COMPOSED OF PRKN; PARK7 AND PINK1; SUBCELLULAR LOCATION; PROTEOLYTIC CLEAVAGE; CHARACTERIZATION OF VARIANTS PARK6 ASP-309 AND MET-313; CHARACTERIZATION OF VARIANT LEU-399;
T313M PINK1 mutation in an extended highly consanguineous Saudi family with early-onset Parkinson disease.
Chishti M.A.; Bohlega S.; Ahmed M.; Loualich A.; Carroll P.; Sato C.; St George-Hyslop P.; Westaway D.; Rogaeva E.;
Arch. Neurol. 63:1483-1485(2006)
Cited for: VARIANT PARK6 MET-313;
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