Variant position: 141 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 219 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human LEGAKDSKKQDPDEQSYSNN SSESHTSSARQLSRNITQHIS
Mouse LEEAKVSEKQSPEEQTHSGR PSDPHVSSTRELLGNATQPTS
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 219 Factor in the germline alpha
124 – 151 Disordered
134 – 151 Polar residues
Increased expression of the FIGLA transcription factor is associated with primordial follicle formation in the human fetal ovary.
Bayne R.A.L.; Martins da Silva S.J.; Anderson R.A.;
Mol. Hum. Reprod. 10:373-381(2004)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; FUNCTION; TISSUE SPECIFICITY; INTERACTION WITH TCF3/E12; VARIANT THR-141;
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
The MGC Project Team;
Genome Res. 14:2121-2127(2004)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 14-219; VARIANT THR-141;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.