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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P07225: Variant p.Gly95Glu

Vitamin K-dependent protein S
Gene: PROS1
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Variant information Variant position: help 95
Type of variant: help LP/P [Disclaimer]
Residue change: help From Glycine (G) to Glutamate (E) at position 95 (G95E, p.Gly95Glu).
Physico-chemical properties: help Change from glycine (G) to medium size and acidic (E)
BLOSUM score: help -2
Variant description: help In THPH5.
Other resources: help


Sequence information Variant position: help 95
Protein sequence length: help 676
Location on the sequence: help DPETDYFYPKYLVCLRSFQT G LFTAARQSTNAYPDLRSCVN
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 42 – 676 Vitamin K-dependent protein S
Region 88 – 116 Thrombin-sensitive
Modified residue 77 – 77 4-carboxyglutamate



Literature citations
Identification of 19 protein S gene mutations in patients with phenotypic protein S deficiency and thrombosis.
Simmonds R.E.; Ireland H.; Kunz G.; Lane D.A.;
Blood 88:4195-4204(1996)
Cited for: VARIANTS THPH5 GLU-50; ALA-67; GLU-95; TYR-186; SER-241; PRO-324; ASP-381; SER-449 AND ARG-666; VARIANT PRO-501;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.