Variant position: 160 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 902 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human DGSPRDYPPPEGFGGYREAG GQGGGAFFSPSPGSSSLSSWS
Mouse DGSPRDYPPPEGFGGYREAG GQGGGAFFSPSPGSSSLSSWS
Rat DGSPRDYPPPEGFGGYREAG GQGGGAFFSPSPGSSSLSSWS
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 902 Nuclear factor of activated T-cells, cytoplasmic 4
16 – 180 Disordered
168 – 168 Phosphoserine; by MAPK7 and MAPK14
170 – 170 Phosphoserine; by MAPK7 and MAPK14
1 – 712 Missing. In isoform 22, isoform 23 and isoform 24.
1 – 465 Missing. In isoform 19, isoform 20 and isoform 21.
168 – 168 S -> A. Promotes nuclear localization and increases transcriptional activity; when associated with A-170.
170 – 170 S -> A. Promotes nuclear localization and increases transcriptional activity; when associated with A-168.
Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins.
Hoey T.; Sun Y.-L.; Williamson K.; Xu X.;
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); FUNCTION; SUBUNIT; VARIANTS ALA-160 AND PRO-800;
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
The MGC Project Team;
Genome Res. 14:2121-2127(2004)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1); NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 61-902 (ISOFORMS 1/2/4/6); VARIANTS ALA-160 AND PRO-800;
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