Variant position: 251 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 366 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human DARDGNEVEPDDDHFSIGVG SRLDGLRNRGPGCTWDSLRNS
Mouse DARDGNEAEPDDDHFSIGVS SRLDGLRNRGPGCTWDSLRNS
Rat DARDGNEAEPDDDHFSIGVS SRLDGLRNRGPGCTWDSLRNS
Bovine DARDGNEAEPEDDHFSIGVG SRLDGLRNRGPGCTWDSLRNS
Xenopus laevis EHRESGETEPEEDQFSVG-- -KLDGSRSRGTACTWDSLRNS
Xenopus tropicalis EHRESGETEPEEDQFSMG-- -KLDGSRGRGTACTWDSLRNS
Zebrafish DMRSSHEAEAEDDTFNMQIG GRLEGGKSKGLGCTWDSLRNS
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 366 RISC-loading complex subunit TARBP2
228 – 366 Sufficient for interaction with DICER1
Characterization of a human TAR RNA-binding protein that activates the HIV-1 LTR.
Gatignol A.; Buckler-White A.J.; Berkhout B.; Jeang K.T.;
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2); VARIANT PHE-251;
Genetic mapping in human and mouse of the locus encoding TRBP, a protein that binds the TAR region of the human immunodeficiency virus (HIV-1).
Kozak C.A.; Gatignol A.; Graham K.; Jeang K.T.; McBride O.W.;
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); VARIANT PHE-251;
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