Variant position: 173 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 689 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human APRV--------SEPGTSSQQSDEILSE SP-------SPSDPVLPLPALIQEGRST
Mouse APRV--------CDPRATAQPIIEILDE QP-------SPSP
Rat GLRI--------RDPGTTSLQITEILDE QP-------SPSH
Baker's yeast REQMERKLAELERKLKTVKDQVLELENN SDVQSLKLRSKED
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 689 Sp110 nuclear body protein
131 – 216 Disordered
155 – 173 Polar residues
175 – 175 Phosphoserine
177 – 177 Phosphoserine
1 – 251 Missing. In isoform 4.
1 – 203 Missing. In isoform 2.
No reference for the current variant in UniProtKB/Swiss-Prot.
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