Variant position: 1067 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 1548 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human IFSAICVGVFADRAYYYGFA SPPSDIAQTTLVGIILSRGTA
Rat IFSAICAGLFADRAYYYGFA SPPTDIEETTYVGIILSRGTA
Pig IFSAICAGLFVERAYYYAFV SPPSGIAETTFVGIILSRGTA
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Cloning of two human thyroid cDNAs encoding new members of the NADPH oxidase family.
De Deken X.; Wang D.; Many M.-C.; Costagliola S.; Libert F.; Vassart G.; Dumont J.E.; Miot F.;
J. Biol. Chem. 275:23227-23233(2000)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; INDUCTION; TISSUE SPECIFICITY; VARIANT LEU-1067;
Tyrosine cross-linking of extracellular matrix is catalyzed by Duox, a multidomain oxidase/peroxidase with homology to the phagocyte oxidase subunit gp91phox.
Edens W.A.; Sharling L.; Cheng G.; Shapira R.; Kinkade J.M.; Lee T.; Edens H.A.; Tang X.; Sullards C.; Flaherty D.B.; Benian G.M.; Lambeth J.D.;
J. Cell Biol. 154:879-891(2001)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; VARIANTS LEU-138 AND LEU-1067; DEVELOPMENTAL STAGE; TISSUE SPECIFICITY;
Purification of a novel flavoprotein involved in the thyroid NADPH oxidase. Cloning of the porcine and human cDNAs.
Dupuy C.; Ohayon R.; Valent A.; Noel-Hudson M.-S.; Deme D.; Virion A.;
J. Biol. Chem. 274:37265-37269(1999)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 339-1548; VARIANT LEU-1067;
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