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UniProtKB/Swiss-Prot Q9NYM4: Variant p.Pro374Gln

G-protein coupled receptor 83
Gene: GPR83
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Variant information Variant position: help 374 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Type of variant: help LB/B The variants are classified into three categories: LP/P, LB/B and US.
  • LP/P: likely pathogenic or pathogenic.
  • LB/B: likely benign or benign.
  • US: uncertain significance

Residue change: help From Proline (P) to Glutamine (Q) at position 374 (P374Q, p.Pro374Gln). Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.
Physico-chemical properties: help Change from medium size and hydrophobic (P) to medium size and polar (Q) The physico-chemical property of the reference and variant residues and the change implicated.
BLOSUM score: help -1 The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page

Other resources: help Links to websites of interest for the variant.


Sequence information Variant position: help 374 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: help 423 The length of the canonical sequence.
Location on the sequence: help IELKALLSMCQRPPKPQEDR P PSPVPSFRVAWTEKNDGQRA The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: help The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human                         IELKALLSMCQRPPKPQEDRPPSPVPSFRVAWTEKNDGQRA

                              IELKALLSMCQRLPKPQEERPPSPVPSFRVAWTEKSNGRRV

Mouse                         VELKALLSMCQRPPKPQEDRLPSPVPSFRVAWTEKSHGRRA

Rat                           VELKALLSMCQRPSKPQEDRLPSPVPSFRVAWTEKSHGRRA

Sequence annotation in neighborhood: help The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.
TypePositionsDescription
Chain 17 – 423 G-protein coupled receptor 83
Topological domain 349 – 423 Cytoplasmic



Literature citations
Y-receptor-like genes GPR72 and GPR73: molecular cloning, genomic organisation and assignment to human chromosome 11q21.1 and 2p14 and mouse chromosome 9 and 6.
Parker R.; Liu M.; Eyre H.J.; Copeland N.G.; Gilbert D.J.; Crawford J.; Sutherland G.R.; Jenkins N.A.; Herzog H.;
Biochim. Biophys. Acta 1491:369-375(2000)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; VARIANT GLN-374; Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.
Nagase T.; Kikuno R.; Ishikawa K.; Hirosawa M.; Ohara O.;
DNA Res. 7:143-150(2000)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]; VARIANT GLN-374; Submission
Kaighin V.A.; Martin A.L.; Aronstam R.S.;
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; VARIANT GLN-374;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.