Variant position: 109 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 112 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human DKTIVGSITNTNFGICHDAG RSKQ
Mouse DRSIIGAITNTNYGICLDSR RSKQ
Rat DRSIIGAITNTNYGVCLDST RSKQ
Pig DKSLVGSITNTNFGICHDVG RSSD
Bovine DKTIVGSITNTNFGVCLDLG RATE
Rabbit DKSIVGSITNTNFGVCLDV- ----
Xenopus tropicalis DRSIVGSITNTDYGYCEDQN NTTI
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
23 – 112 Colipase
Putative association between a new polymorphism in exon 3 (Arg109Cys) of the pancreatic colipase gene and type 2 diabetes mellitus in two independent Caucasian study populations.
Lindner I.; Helwig U.; Rubin D.; Li Y.; Fisher E.; Boeing H.; Mohlig M.; Spranger J.; Pfeiffer A.; Hampe J.; Schreiber S.; Doring F.; Schrezenmeir J.;
Mol. Nutr. Food Res. 49:972-976(2005)
Cited for: VARIANT CYS-109; ASSOCIATION WITH TYPE 2 DIABETES;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.