Variant position: 644 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 918 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human KKKAAAKKMEEVEARRKQEE EARRLRWLQQEEEERRHQELL
Mouse KKKATAKKMEEVEARRKQEE EARRLRWLQQEEEERRHQEML
Chicken KKRAAAKKMEEAEARRRQDE EARKQKALQQEEEERRHKELM
Xenopus tropicalis KKKITAKKQEEVECRRRQEE EARKLKAKQMEEEERRHQDLL
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 918 Inner centromere protein
531 – 765 SAH
Human INCENP colocalizes with the Aurora-B/AIRK2 kinase on chromosomes and is overexpressed in tumour cells.
Adams R.R.; Eckley D.M.; Vagnarelli P.; Wheatley S.P.; Gerloff D.L.; Mackay A.M.; Svingen P.A.; Kaufmann S.H.; Earnshaw W.C.;
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2); SUBCELLULAR LOCATION; VARIANT ASP-644;
Direct association with inner centromere protein (INCENP) activates the novel chromosomal passenger protein, Aurora-C.
Li X.; Sakashita G.; Matsuzaki H.; Sugimoto K.; Kimura K.; Hanaoka F.; Taniguchi H.; Furukawa K.; Urano T.;
J. Biol. Chem. 279:47201-47211(2004)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); FUNCTION; INTERACTION WITH AURKB AND AURKC; SUBCELLULAR LOCATION; PHOSPHORYLATION AT THR-195; VARIANT ASP-644;
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
The MGC Project Team;
Genome Res. 14:2121-2127(2004)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1); VARIANT ASP-644;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.