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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot Q9NQS7: Variant p.Glu644Asp

Inner centromere protein
Gene: INCENP
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Variant information Variant position: help 644
Type of variant: help LB/B
Residue change: help From Glutamate (E) to Aspartate (D) at position 644 (E644D, p.Glu644Asp).
Physico-chemical properties: help Similar physico-chemical property. Both residues are medium size and acidic.
BLOSUM score: help 2
Other resources: help


Sequence information Variant position: help 644
Protein sequence length: help 918
Location on the sequence: help KKKAAAKKMEEVEARRKQEE E ARRLRWLQQEEEERRHQELL
Residue conservation: help 
Human                         KKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRH--QELL

Mouse                         KKKATAKKMEEVEARRKQEEEARRLRWLQQEEEERRH--QE

Chicken                       KKRAAAKKMEEAEARRRQDEEARKQKALQQEEEERRH--KE

Xenopus tropicalis            KKKITAKKQEEVECRRRQEEEARKLKAKQMEEEERRH--QD

Baker's yeast                 --------------MRSQQEHHRR-----------------

Fission yeast                 NVNASWHSN-----MLKRQEDLRKKKPLTDNGATSRHMLKS
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 1 – 918 Inner centromere protein
Region 531 – 765 SAH



Literature citations
Human INCENP colocalizes with the Aurora-B/AIRK2 kinase on chromosomes and is overexpressed in tumour cells.
Adams R.R.; Eckley D.M.; Vagnarelli P.; Wheatley S.P.; Gerloff D.L.; Mackay A.M.; Svingen P.A.; Kaufmann S.H.; Earnshaw W.C.;
Chromosoma 110:65-74(2001)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2); SUBCELLULAR LOCATION; VARIANT ASP-644; Direct association with inner centromere protein (INCENP) activates the novel chromosomal passenger protein, Aurora-C.
Li X.; Sakashita G.; Matsuzaki H.; Sugimoto K.; Kimura K.; Hanaoka F.; Taniguchi H.; Furukawa K.; Urano T.;
J. Biol. Chem. 279:47201-47211(2004)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); FUNCTION; INTERACTION WITH AURKB AND AURKC; SUBCELLULAR LOCATION; PHOSPHORYLATION AT THR-195; VARIANT ASP-644; The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
The MGC Project Team;
Genome Res. 14:2121-2127(2004)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1); VARIANT ASP-644;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.