Sequence information
Variant position: 281 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 393 The length of the canonical sequence.
Location on the sequence:
SGNLLGRNSFEVRVCACPGR
D RRTEEENLRKKGEPHHELPP
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human SGNLLGRNSFEVRVCACPGRD RRTEEENLRKKGEPH--HELPP
SGNVLGRNSFEVRVCACPGRD RRTEEENFHKKGEPC--PEP
Rhesus macaque SGNLLGRNSFEVRVCACPGRD RRTEEENFRKKGEPC--HQL
Mouse SGNLLGRDSFEVRVCACPGRD RRTEEENFRKKEVLC--PEL
Rat SGNLLGRDSFEVRVCACPGRD RRTEEENFRKKEEHC--PEL
Pig SGNLLGRNSFEVRVCACPGRD RRTEEENFLKKGQSC--PEP
Bovine CGNLLGRNSFEVRVCACPGRD RRTEEENLRKKGQSC--PEP
Rabbit SGNLLGRNSFEVRVCACPGRD RRTEEENFRKKGEPC--PEL
Sheep RGNLLGRSSFEVRVCACPGRD RRTEEENFRKKGQSC--PEP
Cat NGKLLGRNSFEVRVCACPGRD RRTEEENFRKKGEPC--PEP
Chicken GGQLLGRRCFEVRVCACPGRD RKIEEENFRKRGGAG-----
Xenopus laevis QGLLLGRRCFEVRVCACPGRD RRTEEDNYTKKRGLK-----
Zebrafish EGQLLGRRSFEVRVCACPGRD RKTEESNFKKDQETKTMAKT
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
1 – 393
Cellular tumor antigen p53
DNA binding
102 – 292
Region
1 – 320
Interaction with CCAR2
Region
100 – 370
Interaction with HIPK1
Region
100 – 300
Required for interaction with ZNF385A
Region
116 – 292
Interaction with AXIN1
Region
256 – 294
Interaction with E4F1
Modified residue
269 – 269
Phosphoserine; by AURKB
Modified residue
284 – 284
Phosphothreonine; by AURKB
Cross
291 – 291
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
Cross
292 – 292
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
Mutagenesis
269 – 269
S -> A. Abolishes phosphorylation.
Mutagenesis
269 – 269
S -> E. Inhibits strongly its transcriptional activity.
Mutagenesis
284 – 284
T -> E. Inhibits strongly its transcriptional activity.
Helix
278 – 287
Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.