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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot Q14162: Variant p.Arg662Trp

Scavenger receptor class F member 1
Gene: SCARF1
Variant information Variant position: help 662 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Type of variant: help LB/B The variants are classified into three categories: LP/P, LB/B and US.
  • LP/P: likely pathogenic or pathogenic.
  • LB/B: likely benign or benign.
  • US: uncertain significance

Residue change: help From Arginine (R) to Tryptophan (W) at position 662 (R662W, p.Arg662Trp). Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.
Physico-chemical properties: help Change from large size and basic (R) to large size and aromatic (W) The physico-chemical property of the reference and variant residues and the change implicated.
BLOSUM score: help -3 The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page

Other resources: help Links to websites of interest for the variant.

Sequence information Variant position: help 662 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: help 830 The length of the canonical sequence.
Location on the sequence: help EAPESFPAAASPGDSATGHR R PPLGGRTVAEHVEAIEGSVQ The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: help The multiple alignment of the region surrounding the variant against various orthologous sequences.


Sequence annotation in neighborhood: help The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.
Chain 20 – 830 Scavenger receptor class F member 1
Topological domain 443 – 830 Cytoplasmic
Region 581 – 688 Disordered
Alternative sequence 338 – 830 Missing. In isoform 4.
Alternative sequence 343 – 830 Missing. In isoform 5.
Alternative sequence 570 – 830 Missing. In isoform 3.

Literature citations
Expression cloning of a novel scavenger receptor from human endothelial cells.
Adachi H.; Tsujimoto M.; Arai H.; Inoue K.;
J. Biol. Chem. 272:31217-31220(1997)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; VARIANTS VAL-425; ASP-639; TRP-662 AND SER-667; Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1.
Nagase T.; Seki N.; Tanaka A.; Ishikawa K.; Nomura N.;
DNA Res. 2:167-174(1995)
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.