Sequence information
Variant position: 2927 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 3177 The length of the canonical sequence.
Location on the sequence:
PAAAKPAPAKPVAAKPVATK
M ATVRPPVAVKPATAAKPVAA
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human PAAAKPAPAKPVAAKPVATKM ATVRPPVAVKPATAAKPVAA
Chicken TTTASTTAQTRATERPTESTT VQVNATVQSQGSTAANTKAT
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
26 – 3177
Collagen alpha-3(VI) chain
Region
2376 – 3177
Nonhelical region
Compositional bias
2908 – 2983
Ala-rich
Alternative sequence
1444 – 3177
Missing. In isoform 3 and isoform 5.
Literature citations
Mosaic structure of globular domains in the human type VI collagen alpha 3 chain: similarity to von Willebrand factor, fibronectin, actin, salivary proteins and aprotinin type protease inhibitors.
Chu M.-L.; Zhang R.-Z.; Pan T.-C.; Stokes D.; Conway D.; Kuo H.-J.; Glanville R.; Mayer U.; Mann K.; Deutzmann R.; Timpl R.;
EMBO J. 9:385-393(1990)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; PARTIAL PROTEIN SEQUENCE; HYDROXYLATION AT PRO-2100; LYS-2103; PRO-2206; LYS-2209; LYS-2212; PRO-2239; PRO-2316; PRO-2319; LYS-2322 AND LYS-2337; VARIANTS VAL-2431; THR-2927; VAL-2988 AND PRO-3012;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.