Variant position: 147 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 456 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human EEANADLEVKIHDWYQKQTP TSPECDYSQYFKTIEELRDKI
Mouse EQANTELEVKIRDWYQKQSP ASPDRDYSHYFKTMEEIRDKI
Rat EEANTELEVKIRDWYQKQSP ASPDRDYSHYFKTMEEIRDKI
Sheep EEANADLEVKIRDWYQRQSP TSPERDYSPYFKTTDELRDKI
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 456 Keratin, type I cytoskeletal 15
105 – 417 IF rod
141 – 159 Linker 1
30 – 194 Missing. In isoform 2.
Low level expression of cytokeratins 8, 18 and 19 in vascular smooth muscle cells of human umbilical cord and in cultured cells derived therefrom, with an analysis of the chromosomal locus containing the cytokeratin 19 gene.
Bader B.L.; Jahn L.; Franke W.W.;
Eur. J. Cell Biol. 47:300-319(1988)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS ALA-147 AND GLY-421;
Molecular characterization and expression of the stratification-related cytokeratins 4 and 15.
Leube R.E.; Bader B.L.; Bosch F.X.; Zimbelmann R.; Achtstaetter T.; Franke W.W.;
J. Cell Biol. 106:1249-1261(1988)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); TISSUE SPECIFICITY; VARIANTS ALA-147 AND GLY-421;
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