UniProtKB/SwissProt variant VAR

Variant information

Variant position:

4536

The position of the amino-acid change on the UniProtKB canonical protein sequence.

Type of variant:

LB/B

The variants are classified into three categories: LP/P, LB/B and US.

LP/P: likely pathogenic or pathogenic.
LB/B: likely benign or benign.
US: uncertain significance

Residue change:

From Glutamate (E) to Glycine (G) at position 4536 (E4536G, p.Glu4536Gly).

Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.

Physico-chemical properties:

Change from medium size and acidic (E) to glycine (G)

The physico-chemical property of the reference and variant residues and the change implicated.

BLOSUM score:

-2

The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:

Lowest score: -4 (low probability of substitution).
Highest score: 11 (high probability of substitution).

More information can be found on the following page

Other resources:

Links to websites of interest for the variant.

Variant rs17357542 [ dbSNP | Ensembl ]

Sequence information

Variant position:

4536

The position of the amino-acid change on the UniProtKB canonical protein sequence.

Protein sequence length:

4544

The length of the canonical sequence.

Location on the sequence:

GSRHSLASTDEKRELLGRGP E DEIGDPLA

The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.

Residue conservation:

The multiple alignment of the region surrounding the variant against various orthologous sequences.

Human                         GSRHSLASTDEKRELLGRGPEDEIGDPLA

Mouse                         GSRHSLASTDEKRELLGRGPEDEIGDPLA

Rat                           GSRHSLASTDEKRELLGRGPEDEIGDPLA

Chicken                       SSRNSLASTDEKRELLARGADDDLTDPLA

Baker's yeast                 -----------------------------

Sequence annotation in neighborhood:

The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:

Type: the type of sequence feature.
Positions: endpoints of the sequence feature.
Description: contains additional information about the feature.

Type	Positions	Description
Chain	20 – 4544	Prolow-density lipoprotein receptor-related protein 1
Chain	3944 – 4544	Low-density lipoprotein receptor-related protein 1 85 kDa subunit
Chain	4441 – 4544	Low-density lipoprotein receptor-related protein 1 intracellular domain
Topological domain	4445 – 4544	Cytoplasmic
Region	4445 – 4544	Interaction with MAFB
Modified residue	4517 – 4517	Phosphoserine
Modified residue	4520 – 4520	Phosphoserine
Modified residue	4523 – 4523	Phosphoserine
Alternative sequence	293 – 4544	Missing. In isoform 2.
Mutagenesis	4517 – 4517	S -> A. Strongly reduced phosphorylation and loss of interaction with SHC1; when associated with A-4460; A-4520 and A-4523.
Mutagenesis	4520 – 4520	S -> A. Strongly reduced phosphorylation and loss of interaction with SHC1; when associated with A-4460; A-4517 and A-4523.
Mutagenesis	4523 – 4523	S -> A. Strongly reduced phosphorylation and loss of interaction with SHC1; when associated with A-4460; A-4517 and A-4520.

Literature citations

No reference for the current variant in UniProtKB/Swiss-Prot.

UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot Q07954: Variant p.Glu4536Gly