Sequence information
Variant position: 4536 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 4544 The length of the canonical sequence.
Location on the sequence:
GSRHSLASTDEKRELLGRGP
E DEIGDPLA
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human GSRHSLASTDEKRELLGRGPE DEIGDPLA
Mouse GSRHSLASTDEKRELLGRGPE DEIGDPLA
Rat GSRHSLASTDEKRELLGRGPE DEIGDPLA
Chicken SSRNSLASTDEKRELLARGAD DDLTDPLA
Baker's yeast --------------------- --------
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
20 – 4544
Prolow-density lipoprotein receptor-related protein 1
Chain
3944 – 4544
Low-density lipoprotein receptor-related protein 1 85 kDa subunit
Chain
4441 – 4544
Low-density lipoprotein receptor-related protein 1 intracellular domain
Topological domain
4445 – 4544
Cytoplasmic
Region
4445 – 4544
Interaction with MAFB
Modified residue
4517 – 4517
Phosphoserine
Modified residue
4520 – 4520
Phosphoserine
Modified residue
4523 – 4523
Phosphoserine
Alternative sequence
293 – 4544
Missing. In isoform 2.
Mutagenesis
4517 – 4517
S -> A. Strongly reduced phosphorylation and loss of interaction with SHC1; when associated with A-4460; A-4520 and A-4523.
Mutagenesis
4520 – 4520
S -> A. Strongly reduced phosphorylation and loss of interaction with SHC1; when associated with A-4460; A-4517 and A-4523.
Mutagenesis
4523 – 4523
S -> A. Strongly reduced phosphorylation and loss of interaction with SHC1; when associated with A-4460; A-4517 and A-4520.
Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.