Variant position: 4536 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 4544 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human GSRHSLASTDEKRELLGRGP EDEIGDPLA
Mouse GSRHSLASTDEKRELLGRGP EDEIGDPLA
Rat GSRHSLASTDEKRELLGRGP EDEIGDPLA
Chicken SSRNSLASTDEKRELLARGA DDDLTDPLA
Baker's yeast -------------------- ---------
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
20 – 4544 Prolow-density lipoprotein receptor-related protein 1
3944 – 4544 Low-density lipoprotein receptor-related protein 1 85 kDa subunit
4441 – 4544 Low-density lipoprotein receptor-related protein 1 intracellular domain
4445 – 4544 Cytoplasmic
4445 – 4544 Interaction with MAFB
4517 – 4517 Phosphoserine
4520 – 4520 Phosphoserine
4523 – 4523 Phosphoserine
293 – 4544 Missing. In isoform 2.
4517 – 4517 S -> A. Strongly reduced phosphorylation and loss of interaction with SHC1; when associated with A-4460; A-4520 and A-4523.
4520 – 4520 S -> A. Strongly reduced phosphorylation and loss of interaction with SHC1; when associated with A-4460; A-4517 and A-4523.
4523 – 4523 S -> A. Strongly reduced phosphorylation and loss of interaction with SHC1; when associated with A-4460; A-4517 and A-4520.
No reference for the current variant in UniProtKB/Swiss-Prot.
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.