Variant position: 9 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 308 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human MPGQELRT VNGSQ------MLLVLLVLSWLPHGGA
Mouse PPALQAQP PGGSQLRFLLFLLLLLLLLSW
Rat LRALHAQP TGGPQLRFLLFLLLLLLLLSW
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 29
Human cDNA encoding a novel TGF-beta superfamily protein highly expressed in placenta.
Yokoyama-Kobayashi M.; Saeki M.; Sekine S.; Kato S.;
J. Biochem. 122:622-626(1997)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; VARIANTS LEU-9 AND THR-48; TISSUE SPECIFICITY;
MIC-1, a novel macrophage inhibitory cytokine, is a divergent member of the TGF-beta superfamily.
Bootcov M.R.; Bauskin A.R.; Valenzuela S.M.; Moore A.G.; Bansal M.; He X.Y.; Zhang H.P.; Donnellan M.; Mahler S.; Pryor K.; Walsh B.J.; Nicholson R.C.; Fairlie W.D.; Por S.B.; Robbins J.M.; Breit S.N.;
Proc. Natl. Acad. Sci. U.S.A. 94:11514-11519(1997)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; VARIANTS LEU-9 AND THR-48;
Cloning and characterization of a novel member of the transforming growth factor-beta/bone morphogenetic protein family.
Paralkar V.M.; Vail A.L.; Grasser W.A.; Brown T.A.; Xu H.; Vukicevic S.; Ke H.Z.; Qi H.; Owen T.A.; Thompson D.D.;
J. Biol. Chem. 273:13760-13767(1998)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; VARIANT LEU-9;
Cloning of human full-length CDSs in BD Creator(TM) system donor vector.
Kalnine N.; Chen X.; Rolfs A.; Halleck A.; Hines L.; Eisenstein S.; Koundinya M.; Raphael J.; Moreira D.; Kelley T.; LaBaer J.; Lin Y.; Phelan M.; Farmer A.;
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]; VARIANTS LEU-9 AND THR-48;
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