Variant position: 82 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 810 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human STTLSTPALSPSSPSQLSPD DLELLAKLEEQNRLLETDSKS
Mouse STTLSTPTQSPSSPSKLSPD DLELLAKLEEQNRLIETDSKS
Drosophila QAKMDVKGGALPGEENLPTS EMDLLAKLEAANKLIESDAKS
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 810 Ecotropic viral integration site 5 protein homolog
1 – 483 Interaction with alpha-tubulin, gamma-tubulin, BIRC5 and FBXO5
28 – 128 Ser-rich
102 – 102 Phosphoserine
NB4S, a member of the TBC1 domain family of genes, is truncated as a result of a constitutional t(1;10)(p22;q21) chromosome translocation in a patient with stage 4S neuroblastoma.
Roberts T.; Chernova O.; Cowell J.K.;
Hum. Mol. Genet. 7:1169-1178(1998)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); TISSUE SPECIFICITY; DISEASE; CHROMOSOMAL TRANSLOCATION WITH TRNG10; VARIANTS VAL-82 AND VAL-336;
Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity.
Ishibashi K.; Kanno E.; Itoh T.; Fukuda M.;
Genes Cells 14:41-52(2009)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2); VARIANTS VAL-82 AND VAL-336;
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