Variant position: 8 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 918 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human MLTLQTW LVQALFIFLTTESTGELLDPC
Mouse MSAPRIW LAQALLFFLTTESIGQLLEPC
Rat MSALRIW LMQALLIFLTTESIGQLVEPC
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 22
Molecular cloning and expression of an IL-6 signal transducer, gp130.
Hibi M.; Murakami M.; Saito M.; Hirano T.; Taga T.; Kishimoto T.;
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); FUNCTION; TISSUE SPECIFICITY; VARIANT VAL-8; SUBUNIT;
Cloning of novel soluble gp130 and detection of its neutralizing autoantibodies in rheumatoid arthritis.
Tanaka M.; Kishimura M.; Ozaki S.; Osakada F.; Hashimoto H.; Okubo M.; Murakami M.; Nakao K.;
J. Clin. Invest. 106:137-144(2000)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2); VARIANT VAL-8; TISSUE SPECIFICITY;
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