Expasy logo

UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P16435: Variant p.Asp252Asn

NADPH--cytochrome P450 reductase
Gene: POR
Feedback?
Variant information Variant position: help 252
Type of variant: help LB/B
Residue change: help From Aspartate (D) to Asparagine (N) at position 252 (D252N, p.Asp252Asn).
Physico-chemical properties: help Change from medium size and acidic (D) to medium size and polar (N)
BLOSUM score: help 1
Other resources: help


Sequence information Variant position: help 252
Protein sequence length: help 677
Location on the sequence: help GVEATGEESSIRQYELVVHT D IDAAKVYMGEMGRLKSYENQ
Residue conservation: help 
Human                         G--VEATGEESSIRQYELV----VHTDID--AAKVYMGEMGR--LKSYENQ

Mouse                         G--VEATGEESSIRQYELV----VHEDMD--TAKVYTGEMG

Rat                           G--VEATGEESSIRQYELV----VHEDMD--VAKVYTGEMG

Pig                           G--VEATGEESSIRQYELV----VHTDMD--TAVVYTGEMG

Bovine                        G--VEATGEESSIRQYELM----VHTDMD--MAKVYTGEMG

Rabbit                        G--VEATGEESSIRQYELV----LHTDID--VAKVYQGEMG

Drosophila                    G--IEGGGEEVLIRQYRLL----EQPDVQ--PDRIYTGEIA

Slime mold                    GYELKSTEDDKFVPRFRMVTLNQDSKDINDPFIKIVSTPLK

Baker's yeast                 H--LDEQ-EAKFTSQFQYT----VLNEI---TDSMSLGEPS

Fission yeast                 H--LQEVHKEYNPM-FEVI----EKPEISNTSSTVFLGEPS
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 2 – 677 NADPH--cytochrome P450 reductase
Topological domain 43 – 677 Cytoplasmic



Literature citations
Submission
NIEHS SNPs program;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS LEU-225; ASN-252 AND VAL-500;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.