Variant position: 226 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 386 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human WSKVYDPLYCESVHNFTLPS WATEDTMTKLRELSELSLLSL
Mouse WSKVYDPLFCESVHNFTLPS WATEDAMIKLKELSELSLLSL
Rat WSRLYDPLYCESVHNFTFRT WATEDAMTKLKELSELSLLSL
Bovine WSKVYDPLFCEGVHNFTLPS WATEDTMTKLKEISELSLLSL
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
33 – 386 Prostatic acid phosphatase
206 – 206 Required for structural stability
220 – 220 N-linked (GlcNAc...) asparagine
161 – 372
215 – 313
206 – 206 W -> F. Greatly reduced enzyme activity, marked decrease in structural stability, and increased binding of the inhibitor, L(+)-tartrate.
206 – 206 W -> L. Reduced enzyme activity, marked decrease in structural stability, and increased binding of the inhibitor, L(+)-tartrate.
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
The MGC Project Team;
Genome Res. 14:2121-2127(2004)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2); VARIANTS ASN-15; VAL-124; ARG-226; HIS-330 AND ALA-360;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.