Sequence information
Variant position: 64 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 814 The length of the canonical sequence.
Location on the sequence:
EAAGTEASSEEVGIAEAGPE
S EVRTEPAAEAEAASGPSESP
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human EAAGTEASSEEVGIAEAGPES EVRTEPAAEAEAASGPSESP
Mouse EVGQTEDAEED---AEAGPEP EVRAKPAAQSEEETATSPAA
Rat EVGRTEDAEED---AEARPEP EVRAKPAAQSEEETAASPAA
Bovine EAAGGED-------AEAGPGP EGPAEPAADGEGKADATPGA
Xenopus laevis --------------------- --------------------
Caenorhabditis elegans --------------------- --------------------
Drosophila --------------------- --------------------
Slime mold --------------------- --------------------
Baker's yeast --------------------- --------------------
Fission yeast --------------------- --------------------
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
1 – 814
Eukaryotic translation initiation factor 3 subunit B
Region
1 – 158
Disordered
Modified residue
78 – 78
Phosphoserine
Modified residue
81 – 81
Phosphoserine
Modified residue
83 – 83
Phosphoserine
Literature citations
Biochemical characterization of mammalian translation initiation factor 3 (eIF3). Molecular cloning reveals that p110 subunit is the mammalian homologue of Saccharomyces cerevisiae protein Prt1.
Chaudhuri J.; Chakrabarti A.; Maitra U.;
J. Biol. Chem. 272:30975-30983(1997)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); FUNCTION; VARIANT PRO-64;
The human homologue of the yeast Prt1 protein is an integral part of the eukaryotic initiation factor 3 complex and interacts with p170.
Methot N.; Rom E.; Olsen H.; Sonenberg N.;
J. Biol. Chem. 272:1110-1116(1997)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2); VARIANT PRO-64;
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
The MGC Project Team;
Genome Res. 14:2121-2127(2004)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1); VARIANT PRO-64;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.