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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P98160: Variant p.Asn765Ser

Basement membrane-specific heparan sulfate proteoglycan core protein
Gene: HSPG2
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Variant information Variant position: help 765
Type of variant: help LB/B
Residue change: help From Asparagine (N) to Serine (S) at position 765 (N765S, p.Asn765Ser).
Physico-chemical properties: help Change from medium size and polar (N) to small size and polar (S)
BLOSUM score: help 1
Other resources: help


Sequence information Variant position: help 765
Protein sequence length: help 4391
Location on the sequence: help CDAHFTRVPGGPYLGTCSGC N CNGHASSCDPVYGHCLNCQH
Residue conservation: help
Human                         CDAHFTRVPGGPYLGTCSGCNCNGHASSCDPVYGHCLNCQH

Mouse                         CDAHFTRVPGGPYLGTCSGCNCNGHASSCDPVYGHCLNCQH

Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 22 – 4391 Basement membrane-specific heparan sulfate proteoglycan core protein
Domain 764 – 813 Laminin EGF-like 2
Disulfide bond 764 – 773



Literature citations
Primary structure of the human heparan sulfate proteoglycan from basement membrane (HSPG2/perlecan). A chimeric molecule with multiple domains homologous to the low density lipoprotein receptor, laminin, neural cell adhesion molecules, and epidermal growth factor.
Murdoch A.D.; Dodge G.R.; Cohen I.; Tuan R.S.; Iozzo R.V.;
J. Biol. Chem. 267:8544-8557(1992)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; VARIANTS VAL-638; SER-765 AND VAL-1503; Human basement membrane heparan sulfate proteoglycan core protein: a 467-kD protein containing multiple domains resembling elements of the low density lipoprotein receptor, laminin, neural cell adhesion molecules, and epidermal growth factor.
Kallunki P.; Tryggvason K.;
J. Cell Biol. 116:559-571(1992)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; VARIANTS VAL-638; SER-765; VAL-1503; HIS-2980; GLY-2995; THR-3168 AND GLN-3632; Perlecan, the major proteoglycan of basement membranes, is altered in patients with Schwartz-Jampel syndrome (chondrodystrophic myotonia).
Nicole S.; Davoine C.-S.; Topaloglu H.; Cattolico L.; Barral D.; Beighton P.; Ben-Hamida C.; Hammouda H.; Cruaud C.; White P.S.; Samson D.; Urtizberea J.A.; Lehmann-Horn F.; Weissenbach J.; Hentati F.; Fontaine B.;
Nat. Genet. 26:480-483(2000)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 22-4391; VARIANTS VAL-638; SER-765 AND VAL-1503; VARIANT SJS1 TYR-1532;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.