Sequence information
Variant position: 4331 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 4391 The length of the canonical sequence.
Location on the sequence:
GEELVSGRSPGPNVAVNAKG
S VYIGGAPDVATLTGGRFSSG
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human GEELVSGRSPGPNVAVNAKGS VYIGGAPDVATLTGGRFSSG
Mouse GEDLVTGRSPGPNVAVNTKDI IYIGGAPDVATLTRGKFSSG
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
22 – 4391
Basement membrane-specific heparan sulfate proteoglycan core protein
Chain
3687 – 4391
Endorepellin
Chain
4197 – 4391
LG3 peptide
Domain
4201 – 4389
Laminin G-like 3
Metal binding
4325 – 4325
Calcium; via carbonyl oxygen
Metal binding
4327 – 4327
Calcium
Mutagenesis
4327 – 4327
N -> A. Retains proper folding. Reduced calcium ion binding.
Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.