Variant position: 230 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 507 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human LIILLGFVQIGK----GDVSNLDP NFSFEGTKLDVGNIVLALYSG
Mouse LIILLGFIQMGKDMGQGDASNLQQ KLSFEGTNLDVGNIVLA
Rat LIILLGFIQMGKDIGQGDASNLHQ KLSFEGTNLDVGNIVLA
Rabbit LIILLGFVQIGK----GGVSNLDP KFSFEGTNWDVGNIVLA
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 507 Large neutral amino acids transporter small subunit 1
215 – 242 Extracellular
246 – 246 A -> V. Nearly abolishes transport activity.
Amino-acid transport by heterodimers of 4F2hc/CD98 and members of a permease family.
Mastroberardino L.; Spindler B.; Pfeiffer R.; Skelly P.J.; Loffing J.; Shoemaker C.B.; Verrey F.;
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; FUNCTION; SUBUNIT; INTERACTION WITH SLC3A2; SUBCELLULAR LOCATION; VARIANT LYS-230;
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