Variant position: 486 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 889 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human YIKTSLSPGSGVVTYYLQES GVMPYLSQLGFDVVGYGCMTC
Mouse YIKTSLSPGSGVVTYYLRES GVMPYLSQLGFDVVGYGCMTC
Rat YVKTSLSPGSGVVTYYLRES GVMPYLSQLGFDVVGYGCMTC
Bovine YIKTSLSPGSGVVTYYLRES GVMPYLSQLGFDVVGYGCMTC
Rabbit YVKTSLSPGSGVVTYYLRES GVMPYLSQLGFDVVGYGCMTC
Chicken YIKTSLSPGSGVVTYYLRES GVMSYLSQLGFDVVGYGCMTC
Caenorhabditis elegans YVKTSLSPGSGVVTKYLEAS GLLPYLEKIGFNIAGYGCMTC
Slime mold YIKTSLSPGSGVVTEYFSHS GLQEPLNKLGFDLTGYGCMTC
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 889 Cytoplasmic aconitate hydratase
503 – 503 Iron-sulfur (4Fe-4S)
506 – 506 Iron-sulfur (4Fe-4S)
503 – 503 C -> S. Loss of aconitase activity. Leads to constitutive RNA binding, irrespective of iron levels.
506 – 506 C -> S. Loss of aconitase activity. Leads of iron levels.
No reference for the current variant in UniProtKB/Swiss-Prot.
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