Variant position: 52 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 325 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human AVKYALSVGYRHIDCAAIYG NEPEIGEALKEDVGPGKAVPR
Mouse AIKHALSAGYRHIDCASVYG NETEIGEALKESVGSGKAVPR
Rat AIKYALSVGYRHIDCASVYG NETEIGEALKESVGAGKAVPR
Pig AIKYALTVGYRHIDCAAIYG NELEIGEALQETVGPGKAVPR
Bovine AIKYALSVGYRHIDCAAIYG NETEIGEALKENVGPGKLVPR
Chicken AVKYALSVGYRHVDCAAAYS NEAEIGDAFQECVGPNKVIKR
Xenopus laevis AVKYALGVGYRHIDCAFVYG NETEVGEAIKESVGPDKGLKR
Xenopus tropicalis AVKYALGVGYRHIDCAFVYG NETEVGEAIKESVGSDKGLSR
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
2 – 325 Aldo-keto reductase family 1 member A1
50 – 50 Proton donor
45 – 45 NADP
38 – 38 Phosphoserine
50 – 50 Y -> F. Complete loss of enzymatic activity.
50 – 50 Y -> H. Complete loss of enzymatic activity.
Two allelic variants of aldo-keto reductase 1A1 exhibit reduced in vitro metabolism of daunorubicin.
Bains O.S.; Takahashi R.H.; Pfeifer T.A.; Grigliatti T.A.; Reid R.E.; Riggs K.W.;
Drug Metab. Dispos. 36:904-910(2008)
Cited for: FUNCTION; CHARACTERIZATION OF VARIANTS SER-52 AND ASP-55;
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