Variant position: 186 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 392 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human SLYVRPVLIGNEPSLGVSQP TRALLFVILCPVGAYFPGGSV
Mouse SLYVRPVLIGNEPSLGVGMV TQALLYVILCPVGSYFPGDSM
Rat SLYVRPVLIGNEPSLGVGMV TQALLFVILCPVGSYFPGDSM
Bovine SLYVRPVLIGNEPSLGVGHP TRALLFVILSPVGAYFPGDAL
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
28 – 392 Branched-chain-amino-acid aminotransferase, mitochondrial
168 – 168 Substrate
Cloning of the rat and human mitochondrial branched chain aminotransferases (BCATm).
Bledsoe R.K.; Dawson P.A.; Hutson S.M.;
Biochim. Biophys. Acta 1339:9-13(1997)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A); VARIANT ARG-186;
Two yeast homologs of ECA39, a target for c-Myc regulation, code for cytosolic and mitochondrial branched-chain amino acid aminotransferases.
Eden A.; Simchen G.; Benvenisty N.;
J. Biol. Chem. 271:20242-20245(1996)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 27-392 (ISOFORM A); VARIANT ARG-186;
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