Variant position: 1075 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 1881 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human ITTDFPLYFVIMSRLCQDYD TIGPEGGSLKSKLVPLVQATF
Mouse ITTDFPLYFVIMSRLCQDYD TIGPEGGSLRSKLVPLVQATF
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 1881 Ankyrin-1
1070 – 1216 ZU5 2
1073 – 1073 Phosphotyrosine
1082 – 1082 Phosphoserine
1 – 1725 Missing. In isoform Mu17, isoform Mu18, isoform Mu19, isoform Mu20, isoform 22 and isoform 23.
1074 – 1076
Analysis of cDNA for human erythrocyte ankyrin indicates a repeated structure with homology to tissue-differentiation and cell-cycle control proteins.
Lux S.E.; John K.M.; Bennett V.;
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ER1 AND ER2); PROTEIN SEQUENCE OF 3-30; 733-753; 828-871; 959-1003; 1106-1128; 1149-1168; 1282-1288; 1345-1367; 1383-1427; 1601-1626; 1686-1700 AND 1763-1772; VARIANTS ALA-750 AND ILE-1075;
cDNA sequence for human erythrocyte ankyrin.
Lambert S.; Yu H.; Prchal J.T.; Lawler J.; Ruff P.; Speicher D.; Cheung M.C.; Kan Y.W.; Palek J.;
Proc. Natl. Acad. Sci. U.S.A. 87:1730-1734(1990)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ER1; ER5 AND ER16); VARIANTS ILE-1075 AND ILE-1546;
Structure and organization of the human ankyrin-1 gene. Basis for complexity of pre-mRNA processing.
Gallagher P.G.; Tse W.T.; Scarpa A.L.; Lux S.E.; Forget B.G.;
J. Biol. Chem. 272:19220-19228(1997)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; ALTERNATIVE SPLICING; VARIANTS LEU-991 AND ILE-1075;
Totoki Y.; Toyoda A.; Takeda T.; Sakaki Y.; Tanaka A.; Yokoyama S.; Ohara O.; Nagase T.; Kikuno R.F.;
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM BR21); VARIANT ILE-1075;
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