Sequence information
Variant position: 161 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 453 The length of the canonical sequence.
Location on the sequence:
PNLQVFPALGNHDYWPQDQL
P VVTSKVYNAVANLWKPWLDE
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human PNLQVFPALGNHDYWPQDQLP VVTSKVYNAVANLWKPWLDE
Mouse PNLQVFPALGNHDYWPQDQLP IVTSKVYSAVADLWKPWLGE
Rat PNLQVFPALGNHDYWPQDQLP IATSKVYSAVSDLWKPWLDE
Bovine PNLQVFPALGNHDYWPQDQLP VVNSKVYNAVANLWKPWLTE
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
23 – 453
Acid sphingomyelinase-like phosphodiesterase 3a
Metal binding
151 – 151
Zinc 2
Binding site
151 – 151
Substrate
Binding site
152 – 152
Substrate
Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.