Variant position: 274 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 529 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human GVINLKDATSKVALVYGQMN EPPGARARVALTGLTVAEYFR
Mouse GVINLKDATSKVALVYGQMN EPPGARARVALTGLTVAEYFR
Rat GVINLKDATSKVALVYGQMN EPPGARARVALTGLTVAEYFR
Bovine GVINLKDATSKVALVYGQMN EPPGARARVALTGLTVAEYFR
Chicken GVINLKDATSKVALVYGQMN EPPGARARVALTGLTVAEYFR
Caenorhabditis elegans GVIDLKGKNSKVSLVYGQMN EPPGARARVCLTGLTVAEYFR
Drosophila GVISLKDKTSKVALVYGQMN EPPGARARVALTGLTVAEYFR
Slime mold GVIKKEGPGSKVALVFGQMN EPPGARARVTLTGLTVAEYFR
Baker's yeast GVINLEGE-SKVALVFGQMN EPPGARARVALTGLTIAEYFR
Fission yeast GVIKLEGE-SKAALVFGQMN EPPGARARVALTGLTVAEYFR
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
48 – 529 ATP synthase subunit beta, mitochondrial
259 – 259 N6-acetyllysine; alternate
259 – 259 N6-succinyllysine; alternate
264 – 264 N6-acetyllysine; alternate
264 – 264 N6-succinyllysine; alternate
Gene structure of the human mitochondrial adenosine triphosphate synthase beta subunit.
Ohta S.; Tomura H.; Matsuda K.; Kagawa Y.;
J. Biol. Chem. 263:11257-11262(1988)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANT GLN-274;
Human F1-ATPase: molecular cloning of cDNA for the beta subunit.
Ohta S.; Kagawa Y.;
J. Biochem. 99:135-141(1986)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; VARIANT GLN-274;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.